ABSTRACT
Objective:To investigate the effect of montelukast sodium tablets combined with ambroxol hydrochloride on immune function and inflammatory factors in children with Mycoplasma pneumoniae pneumonia.Methods:From January 2018 to December 2018, 146 children with Mycoplasma pneumoniae pneumonia admitted in Taizhou Tumor Hospital were randomly divided intoobservation group and control group according the random digital table method, with 73 cases in each group.Both two groups were treated with routine treatment after admission, including continuous low flow oxygen inhalation, sedation, nutritional support, antiasthmatic, expectorant, maintenance of acid-base balance, correction of water electrolyte disorder and anti-infection treatment.The control group was treated with ambroxol hydrochloride, while the observation group was treated with montelukast sodium tablets combined with ambroxol hydrochloride.The course of treatment in both two groups was 2 weeks.The disappearance time of main symptoms, changes of lung function, immune function and inflammatory factors before and after treatment were compared between the two groups.Results:The disappearance time of cough [(3.65±0.87)d], expectoration[(3.49±0.46)d] and fever[(3.32±0.61)d] in the observation group were shorter than those in the control group [(5.54±0.91)d, (5.32±0.71)d and (4.65±0.79)d] ( t=12.827, 18.482, 11.385, all P<0.05). The FEV 1/FVC [(84.36±6.78)%], FEV 1[(2.87±0.54)L] and MVV[(89.74±4.31)L/min] in the observation group were higher than those in the control group[(70.18±7.54)%, (2.05±0.41)L and (82.13±3.78)L/min] ( t=11.948, 10.333, 11.342, all P<0.05). The serum IgA[(0.89±0.14)pg/L], and the IgG[(9.01±0.65)pg/L] and IgM [(1.48±0.21)pg/L] in the observation group were lower than those in the control group [(1.06±0.12)pg/L, (9.81±0.54)pg/L and (1.81±0.15)pg/L] ( t=7.887, 8.089 and 10.925, all P<0.05). The serum levels of TNF-α [(24.13±6.59)mg/L], IL-6[(16.32±5.21)ng/L] and CRP[(7.28±1.43)mg/L] in the observation group were lower than those in the control group[(37.48±8.97)mg/L, (28.78±6.19)ng/L and (18.93±3.45)mg/L](all P<0.05). The total effective rate of the observation group(91.78%) was higher than that of the control group(73.34%)(χ 2=7.180, P<0.05). Conclusion:Montelukast sodium tablet combined with ambroxol hydrochloride has obvious curative effect on children with Mycoplasma pneumoniae pneumonia, and the immune function and inflammatory reaction of children are obviously improved.
ABSTRACT
Objective:To investigate the serum interleukin-32(IL-32) level in children with bacterial pneumonia and its relationship with the severity of the disease.Methods:From January 2019 to December 2019, 300 children with bacterial pneumonia in Taizhou Cancer Hospital were selected as the pneumonia group, and 300 healthy children in our hospital were selected as control group.The serum levels of IL-32, IL-6, IL-8 and tumor necrosis factor-α(TNF-α) were measured by double antibody sandwich enzyme-linked immunosorbent assay.Results:The serum levels of IL-32[(212.46±16.74)ng/L], IL-6[(0.29±0.06)μg/L], IL-8[(0.41±0.08)μg/L] and TNF-α[(1.15±0.11)μg/L] in the pneumonia group were higher than those in the control group[(116.51±14.52)ng/L, (0.07±0.02)μg/L, (0.09±0.03)μg/L, (0.14±0.03)μg/L](all P<0.05). The serum levels of IL-32[(128.76±15.42)ng/L], IL-6[(0.15±0.04)μg/L], IL-8[(0.16±0.05)μg/L] and TNF-α[(0.29±0.06)μg/L] in children with pneumonia during recovery were lower than those in early stage[(212.46±16.74)ng/L, (0.29±0.06)μg/L, (0.41±0.08)μg/L, (1.15±0.11)μg/L](all P<0.05). The levels of serum IL-32[(232.16±16.02)ng/L], IL-6[(0.37±0.08)μg/L], IL-8[(0.54±0.09)μg/L], TNF-α[(1.42±0.15)μg/L] in the severe pneumonia group were higher than those in the non-severe pneumonia group[(184.26±16.31)ng/L, (0.23±0.05)μg/L, (0.26±0.06)μg/L, (0.79±0.12)μg/L](all P<0.05). There were positive correlation between serum IL-32 level and IL-6( r=0.602), IL-8( r=0.624), TNF-α( r=0.593) levels in children with pneumonia(all P<0.05). Conclusion:The serum IL-32 level is elevated in children with bacterial pneumonia.The serum IL-32 level can reflect the therapeutic effect, severity and inflammatory response of children with bacterial pneumonia.